Synergistic work programme in LiSyM-Cancer
LiSyM-Cancer comprises three subprojects - SMART-NAFLD, C-TIP-HCC and DEEP-HCC and the Programme and Data Management. These projects use an integrative systems medicine approach in which liver cell communication, metabolism and signal transduction as well as the dynamics of the different liver cell populations and the composition of the extracellular matrix are examined. High-standard multi- and spatial-OMICS and imaging methods are applied. Based on quantitative data, mathematicians and bioinformaticians develop models to enable the early detection of alterations (tipping points) facilitating liver cancer development. Although most liver cancers develop based on cirrhosis (tipping point 2), due to the rapid increase of overweight and obese patients with NAFLD, the first tipping point is becoming increasingly important.
The three projects in LiSyM-Cancer: SMART-NAFLD characterises the transition from NAFLD directly to HCC (tipping point 1), C-TIP-HCC investigates the transition from liver cirrhosis to HCC (tipping point 2) and DEEP-HCC provides an multi-dimensional characterisation of early HCC.