Prof. Dr. Ursula Klingmüller

Pic of Prof. Dr. Ursula Klingmüller

Head of Division – Systems Biology of Signal Transduction – German Cancer Research Center (DKFZ) Heidelberg

smart-nafld Coordinator

Role in LiSyM-Cancer

  • Coordinator and project leader in SMART-NAFLD
  • Examining signal transduction and metabolism crosstalk and its relation to plasma markers for liver cancer progression
  • Project leader in C-TIP-HCC
  • Emphasizing dynamic pathway modeling of TGFb signal transduction and ECM remodeling in cirrhosis context


  • Combines quantitative analysis with mathematical modeling to understand key regulatory mechanisms in information processing and cell fate decisions.
  • Focuses on signaling pathways in liver regeneration and liver cancer.
  • Advances mass spectrometry-based proteomics for systems medicine, emphasizing absolute quantification of signal transduction proteins and plasma proteins quantification.


  • 2004, Venia Legendi in Cell Biology, Heidelberg University
  • 2000, Habilitation and Venia Legendi in Molecular Biology and Genetics, University of Freiburg
  • 1992, Graduate Studies at Heidelberg University, Doctoral Thesis in Molecular Virology
  • 1988, Diploma in Molecular Biology, Cell Biology and Virology, Heidelberg University
  • 1985, Bachelor of Science, University of Bayreuth

Professional Experience

  • Since 2011, W3 Professor, Heidelberg University, Germany
  • 2003 – 2007, Group Leader of the Theodor-Boveri-Group "Systems Biology and Signal Transduction", DKFZ, Heidelberg
  • 1996 – 2003, Group Leader of an Independent Junior Group (Hans-Spemann-Laboratories), Max-Planck-Institute of Immunobiology, Freiburg, Germany
  • 1993 – 1996, Postdoctoral fellow, Whitehead Institute for Biomedical Research, Cambridge, USA
  • 1992 – 1993, Postdoctoral fellow, Harvard Medical School, Boston, USA

Honors and Awards (selection)

  • Since 2020, Elected EMBO Member
  • 2020 – 2024, Re-election as Member of the German Ethics Council
  • 2016 – 2020, Election as Member of the German Ethics Council
  • 2012 – 2017, Election as Member of the DFG "Hinterzartener Kreis of Cancer Research"