Publications
Impact of Hedgehog modulators on signaling pathways in primary murine and human hepatocytes in vitro: insights into liver metabolism
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Archives of Toxicology
Comparison and evaluation of methods to infer gene regulatory networks from multimodal single-cell data
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preprint
Interleukin 1 β suppresses bile acid-induced BSEP expression via a CXCR2-dependent feedback mechanism
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PLOS ONE
PhosX: data-driven kinase activity inference from phosphoproteomics experiments
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Bioinformatics
Hepatocyte differentiation requires anisotropic expansion of bile canaliculi
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Development
Carborane Conjugates with Ibuprofen, Fenoprofen and Flurbiprofen: Synthesis, Characterization, COX Inhibition Potential and In Vitro Activity
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ChemMedChem
The TGF-beta1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects.
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Biochem Biophys Res Commun
Large language models as a diagnostic support tool in neuropathology
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The Journal of Pathology: Clinical Research
Hepatocellular Cancer Surveillance in Patients with Advanced Chronic Liver Disease.
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NEJM Evid
Beyond hemoglobin: Critical role of 2,3‐bisphosphoglycerate mutase in kidney function and injury
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Acta Physiologica
Decompensated MASH-Cirrhosis Model by Acute and Toxic Effects of Phenobarbital
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Cells
Pregnancy alters fatty acid metabolism, glucose regulation, and detoxification of the liver in synchrony with biomechanical property changes
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Heliyon
Role of WISP1 in Stellate Cell Migration and Liver Fibrosis
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Cells
Identification of PRMT5 as a therapeutic target in cholangiocarcinoma
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Gut
Direct Ingestion of Oxidized Red Blood Cells (Efferocytosis) by Hepatocytes.
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Hepat Med
ProDOL: a general method to determine the degree of labeling for staining optimization and molecular counting
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Nature Methods
Retinoic acid generates a beneficial microenvironment for liver progenitor cell activation in acute liver failure.
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Hepatol Commun
Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice.
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EBioMedicine
Comprehensive evaluation of phosphoproteomic-based kinase activity inference (preprint)
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bioRxiv
Thy‐1 restricts steatosis and liver fibrosis in steatotic liver disease
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Liver International
ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress
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Redox Biology
Terlipressin therapy is associated with increased risk of colonisation with multidrug‐resistant bacteria in patients with decompensated cirrhosis
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Alimentary Pharmacology & Therapeutics
Association between endotoxemia and blood no in the portal circulation of cirrhotic patients: results of a pilot study
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Internal and Emergency Medicine
Lysis buffer selection guidance for mass spectrometry-based global proteomics including studies on the intersection of signal transduction and metabolism (preprint)
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bioRxiv
A liver digital twin for in silico testing of cellular and inter-cellular mechanisms in regeneration after drug-induced damage.
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iScience
Personalised human albumin in patients with cirrhosis and ascites: design and rationale for the ALB-TRIAL - a randomised clinical biomarker validation trial
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BMJ Open
Impact of Viscosity on Human Hepatoma Spheroids in Soft Core–Shell Microcapsules
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Advanced Healthcare Materials
Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease
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Molecular Systems Biology
Insulin Determines Transforming Growth Factor β Effects on Hepatocyte Nuclear Factor 4α Transcription in Hepatocytes
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The American Journal of Pathology
The Interplay of TGF-β1 and Cholesterol Orchestrating Hepatocyte Cell Fate, EMT, and Signals for HSC Activation
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Cellular and Molecular Gastroenterology and Hepatology