Prof. Dr. Steven Dooley

Pic of Prof. Dr. Steven Dooley

University Professor and Head of Section of Molecular Hepatology & Alcohol Associated Diseases – Department of Medicine II – Medical Faculty Mannheim

c-tip-hcc Coordinator

Role in LiSyM-Cancer

  • Coordinator and project leader in C-TIP-HCC


  • Liver cell biology, liver diseases, clinical translation, and systems biology
  • generating quantitative data with cutting edge technologies, e.g. laser-scanning microscopy, 2D/3D quantitative imaging, GeoMx imaging and spatial RNA-profiling, human and mouse liver cells, time-lapse data monitoring, and mouse reporter and disease models

Prof. Dr. Steven Dooley graduated in Biology at the University at Kaiserslautern and did his PhD studies at the Institute of Human Genetics, University of Saarland in Homburg. His Postdoc research on Molecular Cancer Research took place at the Institute of Human Genetics at the same University. Later in 1998, he became Group Leader and Assistant Professor in the Department of Clinical Chemistry and Pathobiochemistry at the University Hospital RWTH Aachen. In 2004, he was appointed as a full Professor to Heidelberg University.

Prof. Dooley received the Gábor-Szász-Award of the Deutsche Vereinte Gesellschaft für Klinische Chemie und Laboratoriums-Medizin for outstanding scientific merits. He has over 200 publications and his work is supported by different grants from, among others, DFG, BMBF and EU. His research is dedicated to cellular processes that occur in the liver in response to damage, e.g. from alcohol abuse or malnutrition, specifically in the role of TGFβ family members, their signaling pathway regulators and target genes. His group is using molecular biology, cell biology, imaging and systems biology in cells, animal models and samples from human patients with liver disease to understand disease mechanisms and find new targets to be used for diagnosis or therapy.