Dr. rer. nat. Silvia Radrezza

Role in LiSyM-Cancer
Due to increasing incidence and high mortality rates, hepatocellular carcinoma (HCC) is an important health problem worldwide. However, its etiopathology and development are poorly understood. While liver metabolism is organized in spatially specific zones, little is known how the zonation is associated with the onset and propagation of liver diseases. To this end, in the lab of Dr. A. Shevchenko, I apply laser capture microdissection (LCM) technique to excise histologically specific features of liver tissues - healthy, marginal and with HCC- and characterize their lipidome and proteome composition.

Expertise
Expert in spatial and clinical lipidomics, proteomics, and mass spectrometry with a background in cell culture and clinical research. Throughout my PhD and postdoc training, I have led and contributed to multi-disciplinary projects investigating the lipidome and/or proteome of healthy and inflamed skin, carcinomas (liver and colon), and metabolic disorders (diabetes). I also specialized in developing and optimising analytical workflows for high-resolution spatial and quantitative lipidomics.

Degrees

• PhD
  2022
  University of Milan
  Quantitative Lipidomics and Proteomics in Medicinal Chemistry

• Master thesis
  2016
  University of Ferrara
  In vitro pharmacological characterization of novel bivalent ligands for NOP and mu-opioid receptors

Honors and Awards

• HelloBio “Lab Heroes Awards” as highly recommended | 2023, sponsored by Hello Bio
• iSLS11th Travel Grant, Singapore | 2023
• Females in Mass Spectrometry (FeMs) Society “Empowerment Award” | 2023
• SOI Journalistic Prize | 2019
• Scholarship: Specialization in Biomedical Research, Institute for Pharmacological Research “Mario Negri” IRCCS, Milan, Italy | 2017 – 2018