Prof. Dr. Julio Saez-Rodriguez

Pic of Prof. Dr. Julio Saez-Rodriguez

Head of Research group and Director of Institute for Computational Biomedicine – Bioquant, Heidelberg University – Faculty of Medicine, Heidelberg University Hospital, Heidelberg

Role in LiSyM-Cancer

  • Project leader in C-TIP-HCC
  • Methods to build dynamic models from large-scale functional data, esp. logic-based models, functional analysis of genomics data in pathway and network-based models
  • Mechanistic models for integrating phospho-proteomic, transcriptomic and metabolomic data with networks


  • functional analysis of transcriptomics data: single-cell and spatial data, multi-omics integration, and understanding multi-cellular communication
  • focus is on cancer, autoimmune diseases, and conditions of the kidney and heart
  • interrogation of large biological data sets with mathematical models to unveil the molecular basis of disease as a means to develop novel therapies
  • use of existing knowledge of biological processes to support computational analysis
  • developing open-source computational tools and co-organization of the DREAM challenges