Prof. Dr. Julio Saez-Rodriguez
Head of Research group and Director of Institute for Computational Biomedicine – Bioquant, Heidelberg University – Faculty of Medicine, Heidelberg University Hospital, Heidelberg
Role in LiSyM-Cancer
- Project leader in C-TIP-HCC
- Methods to build dynamic models from large-scale functional data, esp. logic-based models, functional analysis of genomics data in pathway and network-based models
- Mechanistic models for integrating phospho-proteomic, transcriptomic and metabolomic data with networks
Expertise
- functional analysis of transcriptomics data: single-cell and spatial data, multi-omics integration, and understanding multi-cellular communication
- focus is on cancer, autoimmune diseases, and conditions of the kidney and heart
- interrogation of large biological data sets with mathematical models to unveil the molecular basis of disease as a means to develop novel therapies
- use of existing knowledge of biological processes to support computational analysis
- developing open-source computational tools and co-organization of the DREAM challenges