Program
Monday, 13 May 2024
Welcome
Prof. Dr. Thomas Berg (Head of Hepatology, University Clinics at Leipzig University and host of SBMC 2024)
Prof. Dr. Veronika von Messling (Head of Department 'Life sciences', BMBF)
Prof. Dr. Beat Müllhaupt (Head of Hepatology, University Hospital Zurich and Program Director of LiSyM-Cancer)
Keynote Lecture by Fabian Theis
Talk-Title
Modeling single-cell state and dynamics
Speaker-Info
- Fabian Theis, Helmholtz Munich, München, DE
MTZ Award
Award Ceremony and presentations by the winners of MTZ®-Award for Systems Medicine 2024
Coffee Break
Session 1: From single cell analysis to clinical application
Session 1: Leo van Grunsven
Session-Info
From single cell analysis to clinical application
Talk-Title
Novel insights into liver fibrosis using scRNAseq analysis
Speaker-Info
- Leo van Grunsven, Vrije Universiteit Brussel, Brussels, BE
Session 1: Bjørn Tore Gjertsen
Session-Info
From single cell analysis to clinical application
Talk-Title
Single cell signaling profiling by mass cytometry for early therapy response evaluation in leukemia
Speaker-Info
- Bjørn Tore Gjertsen, University of Bergen, Bergen, NO
Session 1: Fabian Coscia
Session-Info
From single cell analysis to clinical application
Talk-Title
Spatial tissue proteomics to assess health and disease
Speaker-Info
- Fabian Coscia, Max Delbrück Center for Molecular Medicine, Berlin, DE
Session 1: Ayaka Ichikawa
Session-Info
From single cell analysis to clinical application
Talk-Title
ErbB2/HER2 modulates Cyclin D1 and c-Myc dependency at G1/S transition, impacting CDK4 inhibitor sensitivity
Speaker-Info
- Ayaka Ichikawa, Osaka University, Osaka, JP
Session 1: Zixin Huang
Session-Info
From single cell analysis to clinical application
Talk-Title
SMAD3-mediated feedback regulates state- and ligand-specific dynamics in single cells.
Speaker-Info
- Zixin Huang, Technical University Darmstadt, Darmstadt, DE
Poster session & Reception
Poster presentations will be selected from submitted abstracts.
Speakers' Dinner
Tuesday, 14 May 2024
Session 2: Mechanistic modeling at the cellular scale proposing intervention strategies
Session 2: Walter Kolch
Session-Info
Mechanistic modeling at the cellular scale proposing intervention strategies
Talk-Title
Digital Twins for precision oncology
Speaker-Info
- Walter Kolch, University College Dublin, Dublin, IE
Session 2: Jana Wolf
Session-Info
Mechanistic modeling at the cellular scale proposing intervention strategies
Talk-Title
Modeling signal transduction and gene expression in cancer: from information processing to patient specific models
Speaker-Info
- Jana Wolf, Max Delbrück Center for Molecular Medicine, Berlin, DE
Session 2: Dennis Vitkup
Session-Info
Mechanistic modeling at the cellular scale proposing intervention strategies
Talk-Title
Why do cancer cells need oxygen in hypoxia?
Speaker-Info
- Dennis Vitkup, Columbia University Data Science Institute, New York, US
Session 2: Elisa Holstein and Severin Bang
Session-Info
Mechanistic modeling at the cellular scale proposing intervention strategies
Talk-Title
Dynamic pathway modeling of TGFβ and GAS6/AXL induced hepatic stellate cell activation in cirrhosis and liver cancer
Speaker-Info
- Elisa Holstein, German Cancer Research Center, Heidelberg, DE
- Severin Bang, University of Freiburg, Freiburg, DE
Session 2: David Liaskos
Session-Info
Mechanistic modeling at the cellular scale proposing intervention strategies
Talk-Title
From Receptors to Metabolism: Reconstruction and Analysis of Information Flow in Large-Scale Signaling Networks
Speaker-Info
- David Liaskos, École Polytechnique Fédérale de Lausanne, Lausanne, CH
Coffee Break
Session 3: Tissue scale modeling and organ communication in systems medicine
Session 3: Thilo Figge
Session-Info
Tissue scale modeling and organ communication in systems medicine
Talk-Title
Image-based Systems Biology of Fungal Infections in Humans
Speaker-Info
- Thilo Figge, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, DE
Session 3: Fabian Fröhlich
Session-Info
Tissue scale modeling and organ communication in systems medicine
Talk-Title
From allosteric to cell state plasticity, explaining drug resistance in cancer using mathematical modelling.
Speaker-Info
- Fabian Fröhlich, The Francis Crick Institute, London, UK
Lunch
Poster session
Session 3: James Glazier
Session-Info
Tissue scale modeling and organ communication in systems medicine
Talk-Title
Multiscale Virtual Tissue Models and Systems Medicine: Working towards Reproducible and Trustworthy Models
Speaker-Info
- James Glazier, Indiana University Bloomington, Bloomington, US
Session 3: Danish Anwer
Session-Info
Tissue scale modeling and organ communication in systems medicine
Talk-Title
Understanding patient-specific molecular mechanisms in Alzheimer's Disease using in-silico interactome modelling
Speaker-Info
- Danish Anwer, Chalmers Technical University, Gothenburg, SE
Session 3: Christine Wiggins
Session-Info
Tissue scale modeling and organ communication in systems medicine
Talk-Title
Elucidating B Lymphocyte Control: A Systems Biology Approach to Transcriptional Regulation of Humoral Response
Speaker-Info
- Christine Wiggins, Massachusetts Institute of Technology, USA, Cambridge, US
Session 4: AI contributions to systems medicine - Diagnosis and therapy monitoring
Session 4: Ivo Sbalzarini
Session-Info
AI contributions to systems medicine - Diagnosis and therapy monitoring
Talk-Title
Morphogen gradients are regulated by porous media characteristics of embryo geometry
Speaker-Info
- Ivo Sbalzarini, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, DE
Session 4: Hamid Bouchachia
Session-Info
AI contributions to systems medicine - Diagnosis and therapy monitoring
Talk-Title
A Short Overview of AI in Systems Medicine
Speaker-Info
- Hamid Bouchachia, Bournemouth University, Bournemouth, UK
Coffee Break
Session 4: Georg Langs
Session-Info
AI contributions to systems medicine - Diagnosis and therapy monitoring
Talk-Title
TBA
Speaker-Info
- Georg Langs, Medical University of Vienna, Vienna, AU
Session 4: Lena Molitor
Session-Info
AI contributions to systems medicine - Diagnosis and therapy monitoring
Talk-Title
Organellomics: AI-driven deep organellar phenotyping of human neurons
Speaker-Info
- Lena Molitor, Weizmann Institute of Science, Rehovot, IL
Session 4: Nico Kaiser
Session-Info
AI contributions to systems medicine - Diagnosis and therapy monitoring
Talk-Title
Deep learning-based mapping of intact murine kidneys: paving the way to virtual organs
Speaker-Info
- Nico Kaiser, University Medical Center Hamburg-Eppendorf, Hamburg, DE
Interactive Session: Successful implementation of Systems Biology
In this session researchers from all career levels will present their ideas and approaches how systems biology is implemented and the challenges they see for the future of systems biology.
Speaker-Info
- Ursula Klingmüller, German Cancer Research Center (DKFZ), Heidelberg, DE
- Jens Timmer, University of Freiburg, Freiburg, DE
- Sophia Müller-Dott, Institute for Computational Biomedicine, Heidelberg, DE
- Chenhao Tong, University of Heidelberg, Mannheim, DE
- Stefan Höhme, Leipzig University, Leipzig, DE
- Sebastian Burbano de Lara, German Cancer Research Center (DKFZ), Heidelberg, DE
- Lorenz Adlung, University Medical Center Hamburg-Eppendorf, Hamburg, DE
Networking Event
At the networking event there will be opportunity to meet and interact with the speakers and participants of the SBMC 2024. The program will be enriched by a popular science presentation. Including local food and DJ music.
Wednesday, 15 May 2024
Keynote Lecture by Ron Heeren
Talk-Title
Spatial biology and systems medicine in the liver and beyond
Speaker-Info
- Ron Heeren, Maastricht University, Maastricht, NL
Session 5: The future of systems biology
Session 5: Natal van Riel
Session-Info
The future of systems biology
Talk-Title
Personalized computational models and digital twins for precision nutrition and diabetes management
Speaker-Info
- Natal van Riel, Eindhoven University of Technology, Eindhoven, NL
Session 5: Andreas Raue
Session-Info
The future of systems biology
Talk-Title
Applications of Systems Biology in Drug Research and Development
Speaker-Info
- Andreas Raue, Novartis Institutes for BioMedical Research, Cambridge, US
Session 5: Liesbet Geris
Session-Info
The future of systems biology
Talk-Title
TBA
Speaker-Info
- Liesbet Geris, University of Liège, Liège, BE
Coffee Break
Panel discussion: Requirements for systems biology to be translated into the clinic
The Panel Discussion will put the systems medicine developments encountered during the conference into the context of clinical application.
Speaker-Info
- Andreas Raue, Novartis Institutes for BioMedical Research, Cambridge, US
- Ulla Ohlms, Patients' Tumor Bank of Hope, München, DE
- Maria Polychronidou, Molecular Systems Biology, EMBO, Heidelberg, DE
- Thomas Berg, Leipzig University, Leipzig, DE
- Ursula Klingmüller, German Cancer Research Center (DKFZ), Heidelberg, DE
- Stephen Gilbert, Technical University Dresden, Dresden, DE